BDBM144320 US8969336, 558::US8969336, 582

SMILES CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(CC3)C3CCN(C)CC3)c(C)c2)nc1NC1CCOCC1

InChI Key InChIKey=MAIDOSCAFTWGAL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 144320   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Astellas Pharma

US Patent
LigandPNGBDBM144320(US8969336, 582 | US8969336, 558)
Affinity DataIC50: 0.370nMAssay Description:A partial protein of only a kinase domain of FLT3 protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Examp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Astellas Pharma

US Patent
LigandPNGBDBM144320(US8969336, 582 | US8969336, 558)
Affinity DataIC50: 1.10nMAssay Description:A partial protein of only a kinase domain of RET protein was purchased from Carna Biosciences Inc., Japan. The phosphorylation activity toward a pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Astellas Pharma

US Patent
LigandPNGBDBM144320(US8969336, 582 | US8969336, 558)
Affinity DataIC50: 1.20nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent

TargetTyrosine-protein kinase receptor(Human)
Astellas Pharma

US Patent
LigandPNGBDBM144320(US8969336, 582 | US8969336, 558)
Affinity DataIC50: 2.20nMAssay Description:A recombinant retrovirus was created from expression plasmid FLAG-EML4-ALKv1/pMX-iresCD8 in which cDNA for EMLA-ALK fusion protein v1 was integrated,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
US Patent