BDBM14455 3-bromo-4-pyridylacetyl N-oxide 1::4-[2-(4-{6-bromo-13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene}piperidin-1-yl)-2-oxoethyl]-1-oxidopyridin-1-ium::CHEMBL41934

SMILES [#8-]-[n+]1ccc(-[#6]-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ccc(Cl)cc3-[#6]-[#6]-c3cc(Br)cnc-23)cc1

InChI Key InChIKey=QCDHQOJQZWJDKD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 14455   

LigandPNGBDBM14455(3-bromo-4-pyridylacetyl N-oxide 1 | 4-[2-(4-{6-bro...)
Affinity DataIC50:  90nMpH: 7.5 T: 22°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14455(3-bromo-4-pyridylacetyl N-oxide 1 | 4-[2-(4-{6-bro...)
Affinity DataIC50:  90nMAssay Description:Inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM14455(3-bromo-4-pyridylacetyl N-oxide 1 | 4-[2-(4-{6-bro...)
Affinity DataIC50:  90nMAssay Description:FPT inhibitory activity was determined by the ability of the compound to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-ras-C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14455(3-bromo-4-pyridylacetyl N-oxide 1 | 4-[2-(4-{6-bro...)
Affinity DataIC50:  52nMAssay Description:Inhibition of Farnesyl protein transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14455(3-bromo-4-pyridylacetyl N-oxide 1 | 4-[2-(4-{6-bro...)
Affinity DataIC50:  90nMAssay Description:Inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed