BDBM14596 2-[3-Amino-4-(benzylamino)-3-fluoro-1,1-biphenyl-2-yl]-N-{4-[amino(imino)methyl]benzyl}acetamide::2-[6-(3-aminophenyl)-3-(benzylamino)-2-fluorophenyl]-N-[(4-carbamimidoylphenyl)methyl]acetamide::Substituted Benzene Analog 50b

SMILES NC(=N)c1ccc(CNC(=O)Cc2c(F)c(NCc3ccccc3)ccc2-c2cccc(N)c2)cc1

InChI Key InChIKey=COQVFDLYAJKUNP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 14596   

TargetCoagulation factor VII(Human)
Pharmacia

LigandPNGBDBM14596(2-[6-(3-aminophenyl)-3-(benzylamino)-2-fluoropheny...)
Affinity DataIC50: 500nMpH: 8.0 T: 2°CAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
Pharmacia

LigandPNGBDBM14596(2-[6-(3-aminophenyl)-3-(benzylamino)-2-fluoropheny...)
Affinity DataIC50: 1.00E+4nMpH: 8.0 T: 2°CAssay Description:Human thrombin and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Pharmacia

LigandPNGBDBM14596(2-[6-(3-aminophenyl)-3-(benzylamino)-2-fluoropheny...)
Affinity DataIC50: 3.00E+4nMpH: 8.0 T: 2°CAssay Description:Human Factor Xa and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed