BDBM146151 US8957068, 201::US8957068, 202

SMILES COc1ccc(-n2cc(C(C)Nc3nccc(N4C(=O)OC[C@@H]4C(C)C)n3)cn2)cc1

InChI Key InChIKey=LSXSGJKNEVEKER-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 146151   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 146151BDBM146151(US8957068, 202 | US8957068, 201)
Affinity DataIC50: 25nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 146151BDBM146151(US8957068, 202 | US8957068, 201)
Affinity DataIC50: 54.1nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 146151BDBM146151(US8957068, 202 | US8957068, 201)
Affinity DataIC50: 927nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent