BDBM146963 US8957074, 2

SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4C[C@H]5CNC[C@@H](C4)C5O)cn3)nc2n1C1CCCCCC1

InChI Key InChIKey=GYRXBFNBHPDFOA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 146963   

TargetCyclin-dependent kinase 4(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 146963BDBM146963(US8957074, 2)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:An assay for monitoring CDK4/cyclin D1-catalyzed phosphorylation of pRb at the Ser780 site was performed using TR-FRET in a 384-well format, and was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2015
Entry Details
US Patent

TargetCyclin-dependent kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 146963BDBM146963(US8957074, 2)
Affinity DataIC50: 1.50E+4nMT: 2°CAssay Description:A 384-well microtiter IMAP-FP (Molecular Devices Trade Mark Technology) endpoint assay was used for CDK1/cyclin B kinase activity measurements. The s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2015
Entry Details
US Patent