BDBM14759 (R)-6,7-Dimethoxy-4-[3-(pyridin-4-yloxy)-pyrrolidin-1-yl]-quinazoline::6,7-Dimethoxy-4-pyrrolidylquinazoline 20::6,7-dimethoxy-4-[(3R)-3-(pyridin-4-yloxy)pyrrolidin-1-yl]quinazoline

SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccncc3)c2cc1OC

InChI Key InChIKey=IWUVRKQUYQTUCZ-CQSZACIVSA-N

Data  6 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 14759   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rat)
Pfizer

LigandBDBM14759((R)-6,7-Dimethoxy-4-[3-(pyridin-4-yloxy)-pyrrolidi...)Copy SMILESCopy InChI

Affinity DataKi:  112nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
St. John'S University

Curated by ChEMBL

LigandBDBM14759((R)-6,7-Dimethoxy-4-[3-(pyridin-4-yloxy)-pyrrolidi...)Copy SMILESCopy InChI

Affinity DataKi:  112nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Pfizer

LigandBDBM14759((R)-6,7-Dimethoxy-4-[3-(pyridin-4-yloxy)-pyrrolidi...)Copy SMILESCopy InChI

Affinity DataKi:  226nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Pfizer

LigandBDBM14759((R)-6,7-Dimethoxy-4-[3-(pyridin-4-yloxy)-pyrrolidi...)Copy SMILESCopy InChI

Affinity DataKi:  226nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Pfizer

LigandBDBM14759((R)-6,7-Dimethoxy-4-[3-(pyridin-4-yloxy)-pyrrolidi...)Copy SMILESCopy InChI

Affinity DataKi:  685nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Pfizer

LigandBDBM14759((R)-6,7-Dimethoxy-4-[3-(pyridin-4-yloxy)-pyrrolidi...)Copy SMILESCopy InChI

Affinity DataKi:  685nMAssay Description:Inhibition of PDE3BMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL