BDBM15175 6-(4-{[4-(6-methyl-1H-1,3-benzodiazol-2-yl)piperidin-1-yl]methyl}phenyl)-5-phenylpyridine-3-carbonitrile::cyanopyridine 7d

SMILES Cc1ccc2nc(C3CCN(Cc4ccc(-c5ncc(C#N)cc5-c5ccccc5)cc4)CC3)[nH]c2c1

InChI Key InChIKey=KOJPWIUIKNIADX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 15175   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 15175BDBM15175(6-(4-{[4-(6-methyl-1H-1,3-benzodiazol-2-yl)piperid...)
Affinity DataIC50: 2.87E+3nMpH: 7.5 T: 2°CAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2007
Entry Details Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 15175BDBM15175(6-(4-{[4-(6-methyl-1H-1,3-benzodiazol-2-yl)piperid...)
Affinity DataIC50: 1.14E+4nMAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2007
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 15175BDBM15175(6-(4-{[4-(6-methyl-1H-1,3-benzodiazol-2-yl)piperid...)
Affinity DataIC50: 5.00E+4nMAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2007
Entry Details Article
PubMed