BDBM151936 US8987457, 130

SMILES COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1

InChI Key InChIKey=MXLKCGYBUFWTAU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 151936   

TargetSerine/threonine-protein kinase pim-1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 151936BDBM151936(US8987457, 130)
Affinity DataIC50: 0.0300nMAssay Description:Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 151936BDBM151936(US8987457, 130)
Affinity DataIC50: 1.70nMAssay Description:Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 151936BDBM151936(US8987457, 130)
Affinity DataIC50: 2.54nMAssay Description:Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent