BDBM153717 N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-(3-nitrophenoxy)pyrimidin-4-amine (14)

SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Oc2cccc(c2)[N+]([O-])=O)n1

InChI Key InChIKey=HZKIIUFULFKKEU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 153717   

TargetSerine/threonine-protein kinase TBK1(Human)
Technical University of Dortmund

LigandPNGBDBM153717(N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 1.41E+3nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2015
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM153717(N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of wild type EGFR (unknown origin) expressed in Sf9 cells pre-incubated for 30 mins before substrate and ATP addition by homogeneous time-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMed