BDBM153898 US8999981, A143

SMILES C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)CN1CC1CCOCC1

InChI Key InChIKey=WIUOWTNXQICTJG-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 153898   

TargetProtein kinase C beta type(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 153898BDBM153898(US8999981, A143)
Affinity DataKi:  1.90nM ΔG°:  -12.1kcal/molepH: 7.4 T: 2°CAssay Description:Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase PAK 4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 153898BDBM153898(US8999981, A143)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PAK4 Kinase domain (291 to 591 residues) (unknown origin) transfected in TR-293-KDG cells using GEFH1 as substrate assessed as inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 153898BDBM153898(US8999981, A143)
Affinity DataKi:  5.20E+4nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant PAK4 kinase domain (300 to 591 residues) using EVPRRKSLVGTPYWM peptide as substrate assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed