BDBM155098 US9000182, 7, isomer 1

SMILES CO[C@H]1CC[C@@]2(Cc3ccc(cc3[C@]22N=C(C)C(N)=N2)C#CC2CCC2)CC1

InChI Key InChIKey=HZHGVFUZMFVSNM-AGILITTLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 155098   

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandPNGBDBM155098(US9000182, 7, isomer 1)
Affinity DataIC50:  2nMT: 37°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM155098(US9000182, 7, isomer 1)
Affinity DataIC50:  2.70nMpH: 2.5Assay Description:TR-FRET Assay: The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human (3-Secretase (AA 1-AA...More data for this Ligand-Target Pair
In DepthDetails US Patent