BDBM158537 US9034866, 12

SMILES CC(C)(O)C#Cc1ccc2OCC(O)c3sc(nc3-c2c1)C(N)=O

InChI Key InChIKey=KRUKPFJPTKFCTF-UHFFFAOYSA-N

Data  3 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 158537   

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Genentech

US Patent

LigandBDBM158537(US9034866, 12)Copy SMILESCopy InChI

Affinity DataKi:  93nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent

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TargetMitogen-activated protein kinase kinase kinase 14(Human)
Genentech

US Patent

LigandBDBM158537(US9034866, 12)Copy SMILESCopy InChI

Affinity DataKi:  101nMAssay Description:Inhibition of NIK (unknown origin) after 1 to 2 hrs by ADP-FP assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Genentech

Curated by ChEMBL

LigandBDBM158537(US9034866, 12)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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