BDBM160721 US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(pyrimidin-2-yl)piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine

SMILES Clc1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ncccn1

InChI Key InChIKey=VFKYUCXPSFFELL-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160721   

TargetMetabotropic glutamate receptor 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM160721(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(py...)
Affinity DataEC50:  280nMpH: 7.0Assay Description:Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2018
Entry Details
US Patent