BDBM160789 US9682980, 1′-(8-Chloro-3-(cyclopropylmethyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)-2H-spiro[benzofuran-3,4′-piperidin]-2-one

SMILES O=C1OC2C=CC=CC2C12CCN(c1cnn3c(CC4CC4)nnc3c1Cl)CC2

InChI Key InChIKey=MXQJMMWQVRQUAZ-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160789   

TargetMetabotropic glutamate receptor 2(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 160789BDBM160789(US9682980, 1′-(8-Chloro-3-(cyclopropylmethyl...)
Affinity DataEC50:  47nMpH: 7.0Assay Description:Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2018
Entry Details
US Patent