BDBM161934 US10017516, Compound 66::US9682983, 66

SMILES Cc1ccc2c(cccc2n1)-c1cnn2cc(cnc12)-c1ccc(O[C@H]2CCNC2)cn1

InChI Key InChIKey=SQRAKIQIMGAALF-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 161934   

TargetActivin receptor type-1(Human)
The Brigham and Women'S Hospital

US Patent
LigandChemical structure of BindingDB Monomer ID 161934BDBM161934(US9682983, 66 | US10017516, Compound 66)
Affinity DataIC50: 102nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetActivin receptor type-1(Human)
The Brigham and Women'S Hospital

US Patent
LigandChemical structure of BindingDB Monomer ID 161934BDBM161934(US9682983, 66 | US10017516, Compound 66)
Affinity DataIC50: 102nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
The Brigham and Women'S Hospital

US Patent
LigandChemical structure of BindingDB Monomer ID 161934BDBM161934(US9682983, 66 | US10017516, Compound 66)
Affinity DataIC50: 534nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
The Brigham and Women'S Hospital

US Patent
LigandChemical structure of BindingDB Monomer ID 161934BDBM161934(US9682983, 66 | US10017516, Compound 66)
Affinity DataIC50: 534nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
The Brigham and Women'S Hospital

US Patent
LigandChemical structure of BindingDB Monomer ID 161934BDBM161934(US9682983, 66 | US10017516, Compound 66)
Affinity DataIC50: 4.30E+4nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
The Brigham and Women'S Hospital

US Patent
LigandChemical structure of BindingDB Monomer ID 161934BDBM161934(US9682983, 66 | US10017516, Compound 66)
Affinity DataIC50: 4.30E+4nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetActivin receptor type-1B(Human)
The Brigham and Women'S Hospital

US Patent
LigandChemical structure of BindingDB Monomer ID 161934BDBM161934(US9682983, 66 | US10017516, Compound 66)
Affinity DataIC50: 4.43E+4nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetActivin receptor type-1B(Human)
The Brigham and Women'S Hospital

US Patent
LigandChemical structure of BindingDB Monomer ID 161934BDBM161934(US9682983, 66 | US10017516, Compound 66)
Affinity DataIC50: 4.43E+4nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent