BDBM162745 US9056843, 36

SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F

InChI Key InChIKey=MNYTWBQGSPDBNG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 162745   

TargetHistone deacetylase 4(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM162745(US9056843, 36)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of human recombinant TEV-8His-tagged HDAC4 (648 to 1057 residues) expressed in Escherichia coli (DE3) Rosetta cells using Boc-Lys-(Tfa)-AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM162745(US9056843, 36)
Affinity DataIC50: 2.70E+3nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2016
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Novartis

US Patent
LigandPNGBDBM162745(US9056843, 36)
Affinity DataIC50: 1.00E+4nMpH: 8.0 T: 2°CAssay Description:A similar assay procedure as described in Test 2 was used for HDAC1. Human recombinant full length HDAC1 expressed in a baculovirus expression system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2016
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Novartis

US Patent
LigandPNGBDBM162745(US9056843, 36)
Affinity DataIC50: 1.00E+4nMpH: 8.0 T: 2°CAssay Description:A similar assay procedure as described in Test 2 was used for HDAC6. Human recombinant full length HDAC6 expressed in a baculovirus expression system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2016
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM162745(US9056843, 36)
Affinity DataIC50: 1.61E+4nMAssay Description:Inhibition of human recombinant HDAC8 using Boc-Lys-(Tfa)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Novartis

US Patent
LigandPNGBDBM162745(US9056843, 36)
Affinity DataIC50: 5.54E+4nMAssay Description:Inhibition of human recombinant HDAC6 using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Heinrich Heine University Dusseldorf

Curated by ChEMBL
LigandPNGBDBM162745(US9056843, 36)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human recombinant HDAC2 using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed