BDBM162864 US9056843, 155

SMILES CCN(CC)CCNC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F

InChI Key InChIKey=PZAVITOFPPUOOH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 162864   

TargetHistone deacetylase 4(Human)
Novartis

US Patent
LigandPNGBDBM162864(US9056843, 155)
Affinity DataIC50: 12nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2016
Entry Details
US Patent

TargetHistone deacetylase 4(Human)
Novartis

US Patent
LigandPNGBDBM162864(US9056843, 155)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant TEV-8His-tagged HDAC4 (648 to 1057 residues) expressed in Escherichia coli (DE3) Rosetta cells using Boc-Lys-(Tfa)-AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
Novartis

US Patent
LigandPNGBDBM162864(US9056843, 155)
Affinity DataIC50: 17nMAssay Description:Inhibition of GST-tagged HDAC4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 5(Human)TBA
LigandPNGBDBM162864(US9056843, 155)
Affinity DataIC50: 19nMAssay Description:Inhibition of HDAC5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 7(Human)TBA
LigandPNGBDBM162864(US9056843, 155)
Affinity DataIC50: 46nMAssay Description:Inhibition of HDAC7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Novartis

US Patent
LigandPNGBDBM162864(US9056843, 155)
Affinity DataIC50: 2.60E+3nMpH: 8.0 T: 2°CAssay Description:A similar assay procedure as described in Test 2 was used for HDAC6. Human recombinant full length HDAC6 expressed in a baculovirus expression system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2016
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Novartis

US Patent
LigandPNGBDBM162864(US9056843, 155)
Affinity DataIC50: 2.90E+3nMpH: 8.0 T: 2°CAssay Description:A similar assay procedure as described in Test 2 was used for HDAC1. Human recombinant full length HDAC1 expressed in a baculovirus expression system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2016
Entry Details
US Patent

TargetHistone deacetylase 3(Human)TBA
LigandPNGBDBM162864(US9056843, 155)
Affinity DataIC50: 3.82E+3nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Novartis

US Patent
LigandPNGBDBM162864(US9056843, 155)
Affinity DataIC50: 4.02E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 8(Human)TBA
LigandPNGBDBM162864(US9056843, 155)
Affinity DataIC50: 4.26E+3nMAssay Description:Inhibition of human recombinant HDAC8 using Boc-Lys-(Tfa)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Novartis

US Patent
LigandPNGBDBM162864(US9056843, 155)
Affinity DataIC50: 5.79E+3nMAssay Description:Inhibition of human recombinant HDAC6 using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 2(Human)TBA
LigandPNGBDBM162864(US9056843, 155)
Affinity DataIC50: 6.13E+3nMAssay Description:Inhibition of human recombinant HDAC2 using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 11(Human)TBA
LigandPNGBDBM162864(US9056843, 155)
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed