BDBM162865 US9056843, 156

SMILES C[C@H](CN(C)Cc1ccccc1)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F

InChI Key InChIKey=RESDVUQVZOJNSO-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 162865   

TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of recombinant human HDAC4 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 0.850nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2016
Entry Details
US Patent

TargetHistone deacetylase 9(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant human HDAC9 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 7(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human HDAC7 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 5(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human HDAC5 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human HDAC6 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human HDAC8 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human HDAC10 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human HDAC1 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human HDAC11 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human HDAC2 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human HDAC3 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 2.30E+3nMpH: 8.0 T: 2°CAssay Description:A similar assay procedure as described in Test 2 was used for HDAC6. Human recombinant full length HDAC6 expressed in a baculovirus expression system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2016
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 2.90E+3nMpH: 8.0 T: 2°CAssay Description:A similar assay procedure as described in Test 2 was used for HDAC1. Human recombinant full length HDAC1 expressed in a baculovirus expression system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2016
Entry Details
US Patent

TargetHistone deacetylase 1/2/3/8(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of HDAC class 1 in human HT-29 cells using Boc-Lys-Ac as substrate incubated for 3 hrs by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed