BDBM163641 1[2(3Fluorophenyl)5H,6H,7H,8Hpyrazolo[3,2b]quinazolin9yl]piperazine (Inh 6)::US9334288, 7

SMILES Fc1cccc(c1)-c1cc2nc3CCCCc3c(N3CCNCC3)n2n1

InChI Key InChIKey=AFYBBCQVYAHRRH-UHFFFAOYSA-N

Data  3 KI  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 163641   

TargetBeta-glucuronidase(Escherichia coli (strain K12))
University of North Carolina At Chapel Hill

LigandPNGBDBM163641(1[2(3Fluorophenyl)5H,6H,7H,8Hpyrazolo[3,2b]quinazo...)
Affinity DataKi:  670nMAssay Description:Reactions were conducted similarly to the kinetic assays but the reaction consisted of 10 µL assay buffer, 5 µL inhibitor solution, 5 µL of 10 nM enz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-galactosidase(Streptococcus agalactiae (Firmicutes))
University of North Carolina At Chapel Hill

LigandPNGBDBM163641(1[2(3Fluorophenyl)5H,6H,7H,8Hpyrazolo[3,2b]quinazo...)
Affinity DataKi:  2.80E+3nMAssay Description:Reactions were conducted similarly to the kinetic assays but the reaction consisted of 10 µL assay buffer, 5 µL inhibitor solution, 5 µL of 10 nM enz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-galactosidase [V151I,I185V](Clostridium perfringens)
University of North Carolina At Chapel Hill

LigandPNGBDBM163641(1[2(3Fluorophenyl)5H,6H,7H,8Hpyrazolo[3,2b]quinazo...)
Affinity DataKi:  6.10E+3nMAssay Description:Reactions were conducted similarly to the kinetic assays but the reaction consisted of 10 µL assay buffer, 5 µL inhibitor solution, 5 µL of 10 nM enz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-glucuronidase(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM163641(1[2(3Fluorophenyl)5H,6H,7H,8Hpyrazolo[3,2b]quinazo...)
Affinity DataEC50:  913nMAssay Description:PheG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetBeta-glucuronidase(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM163641(1[2(3Fluorophenyl)5H,6H,7H,8Hpyrazolo[3,2b]quinazo...)
Affinity DataIC50:  1.27E+3nMAssay Description:PheG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetBeta-glucuronidase(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM163641(1[2(3Fluorophenyl)5H,6H,7H,8Hpyrazolo[3,2b]quinazo...)
Affinity DataEC50:  811nMAssay Description:PNPG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetBeta-glucuronidase(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM163641(1[2(3Fluorophenyl)5H,6H,7H,8Hpyrazolo[3,2b]quinazo...)
Affinity DataIC50:  8.89E+3nMAssay Description:Inhibition of beta-glucuronidase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-glucuronidase(Human)
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM163641(1[2(3Fluorophenyl)5H,6H,7H,8Hpyrazolo[3,2b]quinazo...)
Affinity DataIC50:  1.20E+3nMAssay Description:PNPG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails US Patent