BDBM164945 US10166239, Ex. 3-40-5::US11406644, Example 3-40-5::US9067914, Ex. 3-40-5

SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1csc(n1)C(F)(F)F

InChI Key InChIKey=JUNWLAORTWKJOM-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 164945   

TargetHigh affinity nerve growth factor receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164945(US10166239, Ex. 3-40-5 | US11406644, Example 3-40-...)
Affinity DataIC50:  0.200nMpH: 7.5 T: 25°CAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetBDNF/NT-3 growth factors receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164945(US10166239, Ex. 3-40-5 | US11406644, Example 3-40-...)
Affinity DataIC50:  0.200nMpH: 7.5 T: 25°CAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In DepthDetails US Patent


LigandPNGBDBM164945(US10166239, Ex. 3-40-5 | US11406644, Example 3-40-...)
Affinity DataIC50:  7nMpH: 7.5 T: 25°CAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetHigh affinity nerve growth factor receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164945(US10166239, Ex. 3-40-5 | US11406644, Example 3-40-...)
Affinity DataIC50:  0.200nMAssay Description:In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetBDNF/NT-3 growth factors receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164945(US10166239, Ex. 3-40-5 | US11406644, Example 3-40-...)
Affinity DataIC50:  0.200nMAssay Description:In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...More data for this Ligand-Target Pair
In DepthDetails US Patent


LigandPNGBDBM164945(US10166239, Ex. 3-40-5 | US11406644, Example 3-40-...)
Affinity DataIC50:  7nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetHigh affinity nerve growth factor receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164945(US10166239, Ex. 3-40-5 | US11406644, Example 3-40-...)
Affinity DataIC50:  0.200nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetBDNF/NT-3 growth factors receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164945(US10166239, Ex. 3-40-5 | US11406644, Example 3-40-...)
Affinity DataIC50:  0.200nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In DepthDetails US Patent


LigandPNGBDBM164945(US10166239, Ex. 3-40-5 | US11406644, Example 3-40-...)
Affinity DataIC50:  7nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetHigh affinity nerve growth factor receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164945(US10166239, Ex. 3-40-5 | US11406644, Example 3-40-...)
Affinity DataIC50:  0.200nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetBDNF/NT-3 growth factors receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164945(US10166239, Ex. 3-40-5 | US11406644, Example 3-40-...)
Affinity DataIC50:  0.200nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In DepthDetails US Patent


LigandPNGBDBM164945(US10166239, Ex. 3-40-5 | US11406644, Example 3-40-...)
Affinity DataIC50:  7nMAssay Description:In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...More data for this Ligand-Target Pair
In DepthDetails US Patent