BDBM165363 US8168651, Compound TABLE 16.30::US9062043, Table 13, Compound 30::US9062043, Table 20b, Compound 21

SMILES OC(=O)c1ccc2c(c1)nc(NCCc1cccc(Cl)c1)c1ccncc21

InChI Key InChIKey=CKWLPIWZGQPVEB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 165363   

TargetCasein kinase II subunit alpha(Human)
Cylene Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 165363BDBM165363(US9062043, Table 20b, Compound 21 | US9062043, Tab...)
Affinity DataIC50: 5nMAssay Description:Test compounds in aqueous solution were added at a volume of 10 microliters, to a reaction mixture comprising 10 microliters Assay Dilution Buffer (A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2023
Entry Details
US Patent

TargetCasein kinase II subunit alpha(Human)
Cylene Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 165363BDBM165363(US9062043, Table 20b, Compound 21 | US9062043, Tab...)
Affinity DataIC50: 5nMpH: 7.2Assay Description:Test compounds in aqueous solution were added at a volume of 10 microliters, to a reaction mixture comprising 10 microliters Assay Dilution Buffer (A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetCasein kinase II subunit alpha'(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165363BDBM165363(US9062043, Table 20b, Compound 21 | US9062043, Tab...)
Affinity DataIC50: 17nMAssay Description:Inhibition of C-terminal Nano-Luc fused human CK2alpha' expressed in HEK293 cells using NanoBRET NanoGlo substrate in presence of tracer K5 by NanoBR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCasein kinase II subunit alpha(Human)
Cylene Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 165363BDBM165363(US9062043, Table 20b, Compound 21 | US9062043, Tab...)
Affinity DataIC50: 230nMAssay Description:Inhibition of C-terminal Nano-Luc fused human CK2alpha expressed in HEK293 cells using NanoBRET NanoGlo substrate in presence of tracer K10 by NanoBR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCasein kinase II subunit alpha(Human)
Cylene Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 165363BDBM165363(US9062043, Table 20b, Compound 21 | US9062043, Tab...)
Affinity DataIC50: 640nMpH: 7.4Assay Description:The human leukemia Jurkat T-cell line was maintained in RPMI 1640 (Cambrex) supplemented with 10% fetal calf serum and 50 ng/ml Geutamycin. Before tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent