BDBM16666 2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-chromene-3-carboxamide::4-(Coumarin-3-yl-carboxamidoethyl)benzenesulfonamide::aromatic sulfonamide compound 31

SMILES NS(=O)(=O)c1ccc(CCNC(=O)c2cc3ccccc3oc2=O)cc1

InChI Key InChIKey=HQMMKFBZUNKWAS-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 16666   

TargetCarbonic anhydrase 2(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM16666(2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-chromene-3...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human recombinant CA2 assessed as inhibition constant incubated for 45 mins by phenol red dye based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCarbonic anhydrase 12(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM16666(2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-chromene-3...)
Affinity DataKi:  9nMAssay Description:Inhibition of human recombinant CA12 assessed as inhibition constant incubated for 45 mins by phenol red dye based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM16666(2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-chromene-3...)
Affinity DataKi:  10nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Mouse)
Universita Degli Studi Di Firenze

LigandPNGBDBM16666(2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-chromene-3...)
Affinity DataKi:  18nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM16666(2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-chromene-3...)
Affinity DataKi:  43nMAssay Description:Inhibition of human recombinant CA5A assessed as inhibition constant incubated for 45 mins by phenol red dye based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCarbonic anhydrase 5B, mitochondrial(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM16666(2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-chromene-3...)
Affinity DataKi:  56nMAssay Description:Inhibition of human recombinant CA5B assessed as inhibition constant incubated for 45 mins by phenol red dye based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM16666(2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-chromene-3...)
Affinity DataKi:  66nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 7(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM16666(2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-chromene-3...)
Affinity DataKi:  93nMAssay Description:Inhibition of human recombinant CA7 assessed as inhibition constant incubated for 45 mins by phenol red dye based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCarbonic anhydrase 4(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM16666(2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-chromene-3...)
Affinity DataKi:  484nMAssay Description:Inhibition of human recombinant CA4 assessed as inhibition constant incubated for 45 mins by phenol red dye based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM16666(2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-chromene-3...)
Affinity DataKi:  740nMAssay Description:Inhibition of human recombinant CA1 assessed as inhibition constant incubated for 45 mins by phenol red dye based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed