BDBM16739 CHEMBL207083::Coumarin Compound, 9b::tert-butyl 4-{4-bromo-2-[(2-oxo-2H-chromene-3-)amido]phenyl}piperazine-1-carboxylate

SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(Br)cc1NC(=O)c1cc2ccccc2oc1=O

InChI Key InChIKey=NKNJPZKXSPBIFO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 16739   

TargetBeta-secretase 1(Human)
Universite De La Mediterranee

LigandPNGBDBM16739(CHEMBL207083 | Coumarin Compound, 9b | tert-butyl ...)
Affinity DataIC50:  1.00E+3nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-secretase 1(Human)
Universite De La Mediterranee

LigandPNGBDBM16739(CHEMBL207083 | Coumarin Compound, 9b | tert-butyl ...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-secretase 1(Human)
Universite De La Mediterranee

LigandPNGBDBM16739(CHEMBL207083 | Coumarin Compound, 9b | tert-butyl ...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed