BDBM167699 US9073922, 186::US9796708, Example 186

SMILES COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1

InChI Key

Data  17 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 167699   

TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent

LigandBDBM167699(US9073922, 186 | US9796708, Example 186)Copy SMILES

Affinity DataIC50:  4nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent

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TargetCyclin-dependent kinase 8(Human)
Nankai University

Curated by ChEMBL

LigandBDBM167699(US9073922, 186 | US9796708, Example 186)Copy SMILES

Affinity DataIC50:  3.11E+3nMAssay Description:Blocking activity against Beta-1 adrenergic receptor in spontaneously beating guinea pig atrial preparationsMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent

LigandBDBM167699(US9073922, 186 | US9796708, Example 186)Copy SMILES

Affinity DataIC50:  1.20nMAssay Description:Inhibition of CDK9 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetCyclin-dependent kinase 4(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM167699(US9073922, 186 | US9796708, Example 186)Copy SMILES

Affinity DataIC50:  155nMAssay Description:Inhibition of CDK4 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetCyclin-dependent kinase 6(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM167699(US9073922, 186 | US9796708, Example 186)Copy SMILES

Affinity DataIC50:  298nMAssay Description:Inhibition of CDK6 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetCyclin-dependent kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM167699(US9073922, 186 | US9796708, Example 186)Copy SMILES

Affinity DataIC50: >1.36E+3nMAssay Description:Inhibition of CDK1 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetCyclin-dependent kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM167699(US9073922, 186 | US9796708, Example 186)Copy SMILES

Affinity DataIC50: >1.36E+3nMAssay Description:Inhibition of CDK2 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetCyclin-dependent kinase 7(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM167699(US9073922, 186 | US9796708, Example 186)Copy SMILES

Affinity DataIC50: >1.36E+3nMAssay Description:Inhibition of CDK7 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetCyclin-dependent kinase 8(Human)
Nankai University

Curated by ChEMBL

LigandBDBM167699(US9073922, 186 | US9796708, Example 186)Copy SMILES

Affinity DataIC50: >1.36E+3nMAssay Description:Inhibition of CDK8 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent

LigandBDBM167699(US9073922, 186 | US9796708, Example 186)Copy SMILES

Affinity DataIC50:  28nMAssay Description:Inhibition of CDK9 in human A-431 cells assessed as reduction in RNA polymerase2 phosphorylation at ser2 residue incubated for 4 hrs by In-cell Weste...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent

LigandBDBM167699(US9073922, 186 | US9796708, Example 186)Copy SMILES

Affinity DataIC50:  1.20nMAssay Description:Blocking activity against Beta-1 adrenergic receptor in spontaneously beating guinea pig atrial preparationsMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL

TargetCyclin-dependent kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM167699(US9073922, 186 | US9796708, Example 186)Copy SMILES

Affinity DataIC50:  3.04E+3nMAssay Description:Blocking activity against Beta-1 adrenergic receptor in spontaneously beating guinea pig atrial preparationsMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetCyclin-dependent kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM167699(US9073922, 186 | US9796708, Example 186)Copy SMILES

Affinity DataIC50:  1.36E+3nMAssay Description:Blocking activity against Beta-1 adrenergic receptor in spontaneously beating guinea pig atrial preparationsMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL

TargetCyclin-dependent kinase 4(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM167699(US9073922, 186 | US9796708, Example 186)Copy SMILES

Affinity DataIC50:  16nMAssay Description:Blocking activity against Beta-2 adrenergic receptor in guinea pig tracheal stripsMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetCyclin-dependent kinase 6(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM167699(US9073922, 186 | US9796708, Example 186)Copy SMILES

Affinity DataIC50:  298nMAssay Description:Blocking activity against Beta-2 adrenergic receptor in guinea pig tracheal stripsMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL

TargetCyclin-dependent kinase 7(Human)
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM167699(US9073922, 186 | US9796708, Example 186)Copy SMILES

Affinity DataIC50: >2.00E+4nMAssay Description:Blocking activity against Beta-1 adrenergic receptor in spontaneously beating guinea pig atrial preparationsMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Abbvie

US Patent

LigandBDBM167699(US9073922, 186 | US9796708, Example 186)Copy SMILES

Affinity DataIC50:  4nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent

Copy BDB DOI
Copy reaction URL