BDBM167912 N,N-diethylcarbamic acid-4-(5-hydroxy-6,7-dimethoxy-4-oxo-4H-1-benzopyran-2-yl)phenyl ester (7j)

SMILES CCN(CC)C(=O)Oc1ccc(cc1)-c1cc(=O)c2c(O)c(OC)c(OC)cc2o1

InChI Key InChIKey=BCPMGKFDBYFFIG-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 167912   

TargetAcetylcholinesterase(Rat)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM167912(N,N-diethylcarbamic acid-4-(5-hydroxy-6,7-dimethox...)
Affinity DataIC50: 570nMAssay Description:Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM167912(N,N-diethylcarbamic acid-4-(5-hydroxy-6,7-dimethox...)
Affinity DataIC50: 570nMAssay Description:For rat AChE or BuChE inhibition assays, a reaction mixture (100 μL) containing acetylthiocholine iodide (1 mmol/L, 30 μL) (J&K Scientific)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM167912(N,N-diethylcarbamic acid-4-(5-hydroxy-6,7-dimethox...)
Affinity DataIC50: 570nMAssay Description:Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Rat)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM167912(N,N-diethylcarbamic acid-4-(5-hydroxy-6,7-dimethox...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of rat cortex homogenate AChE preincubated for 5 mins followed by compound addition and measured after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCarboxylic ester hydrolase(Rat)
Shaanxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM167912(N,N-diethylcarbamic acid-4-(5-hydroxy-6,7-dimethox...)
Affinity DataIC50: 2.21E+4nMAssay Description:Inhibition of rat serum homogenate BuChE preincubated for 5 mins followed by compound addition and measured after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCarboxylic ester hydrolase(Rat)
Shaanxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM167912(N,N-diethylcarbamic acid-4-(5-hydroxy-6,7-dimethox...)
Affinity DataIC50: 2.26E+4nMAssay Description:Inhibition of rat serum BChE using butyrylthiocholine iodide as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCarboxylic ester hydrolase(Rat)
Shaanxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM167912(N,N-diethylcarbamic acid-4-(5-hydroxy-6,7-dimethox...)
Affinity DataIC50: 2.26E+4nMAssay Description:For rat AChE or BuChE inhibition assays, a reaction mixture (100 μL) containing acetylthiocholine iodide (1 mmol/L, 30 μL) (J&K Scientific)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2016
Entry Details Article
PubMed