BDBM17347 (3R,6S,9aR)-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-6-[(2S)-2-(methylamino)propanamido]-5-oxo-octahydroazepino[2,1-b][1,3]thiazole-3-carboxamide::peptide isostere, 10
SMILES [H][C@@]12CCC[C@H](NC(=O)[C@H](C)NC)C(=O)N1[C@@H](CS2)C(=O)Nc1cc(C)nn1-c1ccccc1
InChI Key InChIKey=YYBUDMKKCZIZQP-TXJVSEOTSA-N
Data 5 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 17347
Affinity DataKi: 110nM ΔG°: -9.39kcal/molepH: 7.2 T: 2°CAssay Description:Samples for fluorescence polarization affinity measurements were prepared by addition of serial dilutions of target protein to each well containing a...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
University Of Pittsburgh
Curated by ChEMBL
University Of Pittsburgh
Curated by ChEMBL
Affinity DataKi: 270nMAssay Description:Inhibition of XIAP by FP assayMore data for this Ligand-Target Pair
Affinity DataKi: 270nM ΔG°: -8.86kcal/molepH: 7.2 T: 2°CAssay Description:Samples for fluorescence polarization affinity measurements were prepared by addition of serial dilutions of target protein to each well containing a...More data for this Ligand-Target Pair
TargetComplex of Baculoviral IAP repeat-containing protein 7 [1-159,S150G] and E3 ubiquitin-protein ligase XIAP [336-348](Homo sapiens (Human))
Genentech
Genentech
Affinity DataKi: 280nM ΔG°: -8.84kcal/molepH: 7.2 T: 2°CAssay Description:Samples for fluorescence polarization affinity measurements were prepared by addition of serial dilutions of target protein to each well containing a...More data for this Ligand-Target Pair
Affinity DataKi: 490nM ΔG°: -8.52kcal/molepH: 7.2 T: 2°CAssay Description:Samples for fluorescence polarization affinity measurements were prepared by addition of serial dilutions of target protein to each well containing a...More data for this Ligand-Target Pair