BDBM174803 US9688676, 60 2-((R)-3-(4-amino-2-oxo-3-(4-phenoxyphenyl)-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)piperidine-1-carbonyl)-4-((R)-3-methoxypyrrolidin-1-yl)-4-methylpent-2-enenitrile

SMILES CO[C@@H]1CCN(C(C)(C)C=C(C#N)C(=O)N2CCC[C@@H](n3c(=O)n(-c4ccc(Oc5ccccc5)cc4)c4c(N)nccc43)C2)C1

InChI Key InChIKey=NGUPDWFQNJZNIY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 174803   

TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 174803BDBM174803(US9688676, 60 2-((R)-3-(4-amino-2-oxo-3-(4-phenoxy...)
Affinity DataIC50: 2.40nMT: 2°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of BTK kinase activity of a compound of the pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2018
Entry Details
US Patent