BDBM175866 US9688684, Compound 63: 7-(2,3-Difluoro-benzyl)-8-(3-isopropyl-1-phenyl-1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine

SMILES CC(C)c1nn(cc1C1N(Cc2cccc(F)c2F)CCn2nnnc12)-c1ccccc1

InChI Key InChIKey=UQVYSUYJAWIKHY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 175866   

TargetNuclear receptor ROR-gamma [238-497](Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM175866(US9688684, Compound 63: 7-(2,3-Difluoro-benzyl)-8-...)
Affinity DataIC50:  500nMAssay Description:For the assay 12,500 293T cells (DSMZ no ACC 635) per 384 well are seeded in 30 μl inMEM Eagle medium, supplemented with 10% FBS, 2 mM Glutamax,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma [238-497](Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM175866(US9688684, Compound 63: 7-(2,3-Difluoro-benzyl)-8-...)
Affinity DataIC50:  2.50E+4nMpH: 6.8Assay Description:In this assay, a GST-tagged human RORγ ligand binding domain (GST-hRORγ-LBD) interacts with a synthetic biotinylated TRAP220 cofactor pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent