BDBM175898 US9688684, Compound 95: 8-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine

SMILES Cc1cccc(CN2CCn3nnnc3C2c2ccc3OCCOc3c2)c1

InChI Key InChIKey=FLNJGAKMIMIYES-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 175898   

TargetNuclear receptor ROR-gamma [238-497](Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM175898(US9688684, Compound 95: 8-(2,3-Dihydro-benzo[1,4]d...)
Affinity DataIC50:  5.45E+3nMAssay Description:For the assay 12,500 293T cells (DSMZ no ACC 635) per 384 well are seeded in 30 μl inMEM Eagle medium, supplemented with 10% FBS, 2 mM Glutamax,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma [238-497](Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM175898(US9688684, Compound 95: 8-(2,3-Dihydro-benzo[1,4]d...)
Affinity DataIC50:  500nMpH: 6.8Assay Description:In this assay, a GST-tagged human RORγ ligand binding domain (GST-hRORγ-LBD) interacts with a synthetic biotinylated TRAP220 cofactor pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent