BDBM177786 US9120791, Example 1::US9120791, Example 38::US9603854, 38
SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccccc1
InChI Key InChIKey=VYXJULKGMXJVGI-XIFFEERXSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 177786
Affinity DataKi: 1.30nMAssay Description:Inhibition of Bcl2 (unknown origin) after 2 hrs by fluorescein-PUMA based fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Binding affinity to recombinant wild-type Bcl-2 (unknown origin) using peptide probe incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:Binding affinity to recombinant Bcl-2 D103E mutant (unknown origin) using peptide probe incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.70nMAssay Description:Binding affinity to recombinant Bcl-2 D103V mutant (unknown origin) using peptide probe incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.60nMAssay Description:Binding affinity to recombinant Bcl-2 D103Y mutant (unknown origin) using peptide probe incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataKi: 520nMAssay Description:Inhibition of Bcl-xL (unknown origin) after 2 hrs by fluorescein-PUMA based fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMpH: 7.4Assay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMpH: 7.4Assay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...More data for this Ligand-Target Pair