BDBM178166 US10307413, Compound 208::US10391089, Compound 208::US10980794, Cmpd No 208::US11591326, Compound C3::US9675614, 208
SMILES CC(=O)N1CCC(CC1)Nc2cc(ncn2)C(=O)NC[C@@H](CN3CCc4ccccc4C3)O
InChI Key InChIKey=JLCCNYVTIWRPIZ-UHFFFAOYSA-N
Data 9 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 41 hits for monomerid = 178166
Affinity DataEC50: 2nMAssay Description:Inhibition of PRMT5 in human ZR-75-1 cells assessed as decrease in SDMA level incubated for 3 daysMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Inhibition of PRMT5 in human U-2940 cells assessed as decrease in SDMA level incubated for 3 daysMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Inhibition of PRMT5 in human REC1 cells assessed as decrease in SDMA level incubated for 3 daysMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Inhibition of PRMT5 in human BJAB cells assessed as decrease in SDMA level incubated for 3 daysMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Inhibition of PRMT5 in human MINO cells assessed as decrease in SDMA level incubated for 3 daysMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Inhibition of PRMT5 in human MAVER-1 cells assessed as decrease in SDMA level incubated for 3 daysMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Inhibition of PRMT5 in human MCF7 cells assessed as decrease in SDMA level incubated for 3 daysMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Inhibition of PRMT5 in human MDA-MB-468 cells assessed as decrease in SDMA level incubated for 3 daysMore data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on SDMA level incubated for 3 days by ELISA analysisMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using H2A as substrate assessed as...More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using Sm3d as substrate assessed a...More data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using H4 as substrate assessed as ...More data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using [3H]SAM as substrate assesse...More data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using Sm3d as substrate preincubat...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using H2A as substrate preincubate...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Jinan
Curated by ChEMBL
University of Jinan
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H4 as substrate preincubated for 60 mins in presence of enzyme and SAMMore data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using H4 as substrate preincubated...More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using [3H]SAM as substrate preincu...More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 9.5nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using HNRNPH1 as substrate assesse...More data for this Ligand-Target Pair
Affinity DataKi: 9.90nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using FUBP1 as substrate assessed ...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of PRMT5 methyltransferase activity in MTAP knockout human HCT-116 cells assessed as inhibition of PRMT5- mediated SDMA modification level...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of PRMT5 methyltransferase activity in human HCT-116 cells expressing wild type MTAP assessed as inhibition of PRMT5- mediated SDMA modifi...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using HNRNPH1 as substrate preincu...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using FUBP1 as substrate preincuba...More data for this Ligand-Target Pair
Affinity DataEC50: 22nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on SESN1 expression incubated for 2 to 4 days by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Competitive inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using [3H]SAM as subst...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Jinan
Curated by ChEMBL
University of Jinan
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:General Procedure for PRMT5/MEP50 AlphaLISA Enzyme Inhibitory Assays: Assays were performed in the buffer consisting of 50 mM Tris, pH 8.5, 5 mM MgCl...More data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Uncompetitive inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using [3H]SAM as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:After dissolved in dimethyl sulfoxide respectively, the test compounds were added into an Echo Qualified 384-well plate and diluted to the desired co...More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on BAX expression incubated for 2 to 4 days by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 55nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on CDKN1 expression incubated for 2 to 4 days by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Jinan
Curated by ChEMBL
University of Jinan
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
Affinity DataEC50: 167nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on MDM2 expression incubated for 2 to 4 days by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 177nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on PHLDA3 expression incubated for 2 to 4 days by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 212nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on TRIM22 expression incubated for 2 to 4 days by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 214nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on EGR2 expression incubated for 2 to 4 days by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 323nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on GADD45A expression incubated for 2 to 4 days by Western blot analysisMore data for this Ligand-Target Pair