BDBM182336 US9145392, 37

SMILES Cn1cc(nc1C1CCN(CC1)c1ncnc(N)c1C(N)=O)-c1ccc(F)c(c1)C(F)(F)F

InChI Key InChIKey=ODHFZINJDDSFIB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 182336   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Merck Patent

US Patent
LigandPNGBDBM182336(US9145392, 37)
Affinity DataIC50:  1.60E+3nMpH: 7.5Assay Description:A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM182336(US9145392, 37)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM182336(US9145392, 37)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Merck Patent

US Patent
LigandPNGBDBM182336(US9145392, 37)
Affinity DataIC50:  2.60nMpH: 7.5 T: 25°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In DepthDetails US Patent