BDBM182377 US9145392, 78
SMILES NC(=O)c1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCC1)-c1ccc(F)c(c1)C(F)(F)F
InChI Key InChIKey=WNBFWWDKYZWYOX-UHFFFAOYSA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 182377
Affinity DataIC50: 14nMpH: 7.5Assay Description:A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 2B6(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 2C8(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: 1.74E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair