BDBM18374 CHEMBL394937::Pyrrole-based compound, 30::sodium (3R,5R)-7-[3-(4-fluorophenyl)-4-phenyl-5-(phenylcarbamoyl)-1-(propan-2-yl)-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoate

SMILES CC(C)n1c(CC[C@@H](O)C[C@@H](O)CC([O-])=O)c(c(c1C(=O)Nc1ccccc1)-c1ccccc1)-c1ccc(F)cc1

InChI Key InChIKey=PNRWKVJLHGHICL-UHFFFAOYSA-M

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 18374   

LigandPNGBDBM18374(sodium (3R,5R)-7-[3-(4-fluorophenyl)-4-phenyl-5-(p...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM18374(sodium (3R,5R)-7-[3-(4-fluorophenyl)-4-phenyl-5-(p...)
Affinity DataIC50: 12nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed