BDBM1855 3-{[2,5-bis(propan-2-yl)phenyl]sulfanyl}-4-hydroxy-6,6-diphenyl-5,6-dihydro-2H-pyran-2-one::4-Hydroxy-5,6-dihydropyrone deriv. 46::5,6-Dihydro-4-hydroxy-6,6-diphenyl-3-[(2,5-diisopropylphenyl)sulfanyl]-2H-pyran-2-one

SMILES CC(C)c1ccc(C(C)C)c(SC2C(=O)CC(OC2=O)(c2ccccc2)c2ccccc2)c1

InChI Key InChIKey=FMHIDHSGXQFCAG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 1855   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM1855(3-{[2,5-bis(propan-2-yl)phenyl]sulfanyl}-4-hydroxy...)
Affinity DataIC50: 119nMAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2004
Entry Details Article
PubMed