BDBM188461 US9169224, 150::US9688664, Comparator Compound

SMILES FC1(F)Oc2ccc(CN3CCN(CC3)C(=O)Nc3cccnc3)cc2O1

InChI Key InChIKey=RFSSDZNSBWBBLR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 188461   

TargetFatty-acid amide hydrolase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM188461(US9688664, Comparator Compound | US9169224, 150)
Affinity DataIC50: 130nMpH: 9.0Assay Description:T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1x15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2016
Entry Details
US Patent

TargetFatty-acid amide hydrolase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM188461(US9688664, Comparator Compound | US9169224, 150)
Affinity DataIC50: 290nMpH: 9.0Assay Description:T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1x15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2016
Entry Details
US Patent

TargetFatty-acid amide hydrolase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM188461(US9688664, Comparator Compound | US9169224, 150)
Affinity DataIC50: 340nMpH: 9.0Assay Description:T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1×15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetFatty-acid amide hydrolase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM188461(US9688664, Comparator Compound | US9169224, 150)
Affinity DataIC50: 450nMpH: 9.0Assay Description:Transfected SK-N-MC cells (contents of 1×15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0.2% Glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM188461(US9688664, Comparator Compound | US9169224, 150)
Affinity DataIC50: 2.00E+3nMpH: 7.4Assay Description:The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM188461(US9688664, Comparator Compound | US9169224, 150)
Affinity DataIC50: 3.20E+3nMpH: 7.4Assay Description:The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent