BDBM18948 2-(3,5-dibromo-4-{4-hydroxy-3-[(2-phenylethyl)carbamoyl]phenoxy}phenyl)acetic acid::4-hydroxy thyromimetic, 15c

SMILES OC(=O)Cc1cc(Br)c(Oc2ccc(O)c(c2)C(=O)NCCc2ccccc2)c(Br)c1

InChI Key InChIKey=UMGUSXFHBSNVGH-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 18948   

TargetThyroid hormone receptor alpha(Human)
Bristol-Myers Squibb

LigandPNGBDBM18948(2-(3,5-dibromo-4-{4-hydroxy-3-[(2-phenylethyl)carb...)
Affinity DataIC50:  15nMAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThyroid hormone receptor beta(Human)
Bristol-Myers Squibb

LigandPNGBDBM18948(2-(3,5-dibromo-4-{4-hydroxy-3-[(2-phenylethyl)carb...)
Affinity DataIC50:  0.620nMAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetThyroid hormone receptor beta(Human)
Bristol-Myers Squibb

LigandPNGBDBM18948(2-(3,5-dibromo-4-{4-hydroxy-3-[(2-phenylethyl)carb...)
Affinity DataIC50:  0.617nMAssay Description:Inhibition of thyroid hormone receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetThyroid hormone receptor alpha(Human)
Bristol-Myers Squibb

LigandPNGBDBM18948(2-(3,5-dibromo-4-{4-hydroxy-3-[(2-phenylethyl)carb...)
Affinity DataIC50:  15.1nMAssay Description:Inhibition of thyroid hormone receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThyroid hormone receptor beta(Human)
Bristol-Myers Squibb

LigandPNGBDBM18948(2-(3,5-dibromo-4-{4-hydroxy-3-[(2-phenylethyl)carb...)
Affinity DataIC50:  0.617nMAssay Description:Inhibition of human thyroid hormone receptor beta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)