BDBM18995 Pyrazolopyridinone analogue, 21::tert-butyl N-{6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-3-yl}carbamate

SMILES COc1ccc(cc1)-n1nc(NC(=O)OC(C)(C)C)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1

InChI Key InChIKey=ZGFNARQDWZHFIU-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 18995   

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM18995(tert-butyl N-{6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1...)
Affinity DataKi:  9.60nM ΔG°:  -10.8kcal/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb

LigandPNGBDBM18995(tert-butyl N-{6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1...)
Affinity DataKi:  4.60E+3nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2007
Entry Details Article
PubMed