BDBM190709 US9181236, 13
SMILES C[C@]1(CS(=O)(=O)C2(CCCC2)C(=N)N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
InChI Key InChIKey=DMEAWTNLOAGORR-FQEVSTJZSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 190709
Affinity DataKi: 0.300nM ΔG°: -13.2kcal/molepH: 5.0 T: 30°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a
time-resolved endpoint proteolysis assay that measures hydrolysis of the
QSY7-EISE...More data for this Ligand-Target Pair
Affinity DataKi: 3.10nM ΔG°: -11.8kcal/molepH: 5.0 T: 30°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo...More data for this Ligand-Target Pair