BDBM190713 US9181236, 17
SMILES COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CS(=O)(=O)C2(CCCC2)C(=N)N1
InChI Key InChIKey=GXWQCTDIXFWINS-FQEVSTJZSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 190713
Affinity DataKi: 1.5nM ΔG°: -12.2kcal/molepH: 5.0 T: 30°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a
time-resolved endpoint proteolysis assay that measures hydrolysis of the
QSY7-EISE...More data for this Ligand-Target Pair
Affinity DataKi: 3.60nM ΔG°: -11.7kcal/molepH: 5.0 T: 30°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo...More data for this Ligand-Target Pair