BDBM193021 US9193726, 9

SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(Cl)cc1C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O

InChI Key InChIKey=MUDLWRHYTYCFBR-UZQPLGKSSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 193021   

TargetPresenilin-1(Human)
Pfizer

US Patent
LigandPNGBDBM193021(US9193726, 9)
Affinity DataIC50:  9.10nMT: 37°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetPresenilin-1(Human)
Pfizer

US Patent
LigandPNGBDBM193021(US9193726, 9)
Affinity DataEC50:  9nMAssay Description:Modulation of gamma-secretase in CHO cells expressing human APP assessed as reduction in amyloid beta (1 to 42 residues) production after 24 hrs by E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Human)
Pfizer

US Patent
LigandPNGBDBM193021(US9193726, 9)
Affinity DataIC50:  9nMAssay Description:Inhibition of gamma-secretase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed