BDBM193078 6-(3-hydroxy-3-methylbutyl)-4-(6-(6-((6- methoxypyridin-3-yl)methyl)-3,6- diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5- a]pyridine-3-carbonitrile::US12516054, Compound 10::US20260078123, Compound 10

SMILES COc1ccc(CN2C3CC2CN(c2ccc(-c4cc(CCC(C)(C)O)cn5ncc(C#N)c45)cn2)C3)cn1

InChI Key InChIKey=GRCCNVZFHYNCFN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 193078   

TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114](Human)
Shanghai Daidai Investment Consulting

US Patent
LigandChemical structure of BindingDB Monomer ID 193078BDBM193078(6-(3-hydroxy-3-methylbutyl)-4-(6-(6-((6- methoxypy...)
Affinity DataIC50: 5.60nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2026
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114](Human)
Shanghai Daidai Investment Consulting

US Patent
LigandChemical structure of BindingDB Monomer ID 193078BDBM193078(6-(3-hydroxy-3-methylbutyl)-4-(6-(6-((6- methoxypy...)
Affinity DataIC50: 5.60nMAssay Description:The ability of compounds to antagonize human A2A and A2B adenosine receptors was determined using a kit to measure changes in intracellular cyclic AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2026
Entry Details
US Patent