BDBM194681 US10717737, Example 69::US11247992, Example 69::US9670210, Example 69 1-{[4-[(6-methoxypyridin-3-yl)methyl]-4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)piperidin-1-yl]methyl}cyclopropanecarboxylic acid

SMILES COc1ccc(CC2(CN[C@@H]3CC3c3ccccc3)CCN(CC3(CC3)C(O)=O)CC2)cn1

InChI Key InChIKey=QZGWONNFYUVCDD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 194681   

TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM194681(US9670210, Example 69 1-{[4-[(6-methoxypyridin-3-y...)
Affinity DataIC50: 100nMAssay Description:LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM194681(US9670210, Example 69 1-{[4-[(6-methoxypyridin-3-y...)
Affinity DataIC50: 100nMAssay Description:LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM194681(US9670210, Example 69 1-{[4-[(6-methoxypyridin-3-y...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent