BDBM195239 US9212153, 304,Ex. 253

SMILES COC1CCC2(Cc3ccc(cc3C22NC(N)N(CCC(N)=O)C2=O)C#CC2CC2)CC1

InChI Key InChIKey=JIGBKIWICHFJFE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 195239   

TargetBeta-secretase 1 [1-458](Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM195239(US9212153, 304,Ex. 253)
Affinity DataIC50:  4.70nMpH: 4.4Assay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent