BDBM195875 US9670213, Compound 020 N-(3-(2-(4-(4-methyl-1-piperazinyl)-phenylamino)-7-oxo-8(7H)-pteridin-yl)phenyl) acrylamide
SMILES CN1CCN(CC1)c1ccc(Nc2ncc3ncc(=O)n(-c4cccc(NC(=O)C=C)c4)c3n2)cc1
InChI Key InChIKey=JJQDZMPHVLCCFS-UHFFFAOYSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 195875
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology
US Patent
East China University of Science and Technology
US Patent
Affinity DataIC50: 1.47nMT: 25°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology
US Patent
East China University of Science and Technology
US Patent
Affinity DataIC50: 1.20nMT: 25°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M,L858R](Human)
East China University of Science and Technology
US Patent
East China University of Science and Technology
US Patent
Affinity DataIC50: 0.820nMT: 25°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
Affinity DataIC50: <14nMT: 25°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Human)
East China University of Science and Technology
Curated by ChEMBL
East China University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 0.677nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology
US Patent
East China University of Science and Technology
US Patent
Affinity DataIC50: 1.20nMAssay Description:Inhibition of wild type EGFR (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 312nMAssay Description:Inhibition of human N-terminal GST-tagged FLT3 (564 to 993 residues) expressed in baculovirus expression system using peptide FAM-P2 as substrate inc...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 322nMT: 25°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair