BDBM196508 US9212165, 16

SMILES O=C(N[C@]12CC[C@](C1)(CCC2)C#Cc1ccccn1)c1ccccn1

InChI Key InChIKey=ISUZZRVMDCKBEJ-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 196508   

TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

US Patent
LigandPNGBDBM196508(US9212165, 16)
Affinity DataIC50: 1.60nMpH: 7.4Assay Description:The rmGluR5 or hmGluR5 was stably expressed in a HEK 293 cell line and gown in Dulbecco's Modified Eagle Medium (DMEM) (Invitrogen, Carlsbad, Cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

US Patent
LigandPNGBDBM196508(US9212165, 16)
Affinity DataKi:  4.5nM ΔG°:  -11.4kcal/molepH: 7.4 T: 2°CAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details
US Patent