BDBM198244 US9216999, 52::US9556187, Example 52

SMILES FC(F)(F)c1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cn1

InChI Key InChIKey=DOPMYOXHSDZPKV-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 198244   

TargetTyrosine-protein kinase JAK1(Human)
Nissan Chemical Industries

US Patent
LigandChemical structure of BindingDB Monomer ID 198244BDBM198244(US9216999, 52 | US9556187, Example 52)
Affinity DataIC50: 2.10nMpH: 7.5Assay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Nissan Chemical Industries

US Patent
LigandChemical structure of BindingDB Monomer ID 198244BDBM198244(US9216999, 52 | US9556187, Example 52)
Affinity DataIC50: 2.10nMT: 2°CAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nissan Chemical Industries

US Patent
LigandChemical structure of BindingDB Monomer ID 198244BDBM198244(US9216999, 52 | US9556187, Example 52)
Affinity DataIC50: 18nMpH: 7.5Assay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nissan Chemical Industries

US Patent
LigandChemical structure of BindingDB Monomer ID 198244BDBM198244(US9216999, 52 | US9556187, Example 52)
Affinity DataIC50: 18nMT: 2°CAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Nissan Chemical Industries

US Patent
LigandChemical structure of BindingDB Monomer ID 198244BDBM198244(US9216999, 52 | US9556187, Example 52)
Affinity DataIC50: 21nMT: 2°CAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Nissan Chemical Industries

US Patent
LigandChemical structure of BindingDB Monomer ID 198244BDBM198244(US9216999, 52 | US9556187, Example 52)
Affinity DataIC50: 41nMT: 2°CAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Nissan Chemical Industries

US Patent
LigandChemical structure of BindingDB Monomer ID 198244BDBM198244(US9216999, 52 | US9556187, Example 52)
Affinity DataIC50: 41nMpH: 7.5Assay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nissan Chemical Industries

US Patent
LigandChemical structure of BindingDB Monomer ID 198244BDBM198244(US9216999, 52 | US9556187, Example 52)
Affinity DataIC50: 360nMT: 2°CAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nissan Chemical Industries

US Patent
LigandChemical structure of BindingDB Monomer ID 198244BDBM198244(US9216999, 52 | US9556187, Example 52)
Affinity DataIC50: 360nMpH: 7.5Assay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details
US Patent