BDBM198512 US9216999, 309::US9556187, Example 309

SMILES OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(C[C@H]2CC[C@H](c3nnn4cnc5[nH]ccc5c34)CC2)CC1

InChI Key InChIKey=VTJKQNPPOZUBTM-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 198512   

TargetTyrosine-protein kinase JAK1(Human)
Nissan Chemical Industries

US Patent
LigandChemical structure of BindingDB Monomer ID 198512BDBM198512(US9216999, 309 | US9556187, Example 309)
Affinity DataIC50: 7.60nMT: 2°CAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nissan Chemical Industries

US Patent
LigandChemical structure of BindingDB Monomer ID 198512BDBM198512(US9216999, 309 | US9556187, Example 309)
Affinity DataIC50: 97nMT: 2°CAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nissan Chemical Industries

US Patent
LigandChemical structure of BindingDB Monomer ID 198512BDBM198512(US9216999, 309 | US9556187, Example 309)
Affinity DataIC50: 310nMT: 2°CAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent