BDBM198912 US9221802, Ref. Ex. 79::US9315498, 79

SMILES CC1(C)CCN(C(=O)O1)c1ccc(cn1)C#Cc1ccc(F)cc1

InChI Key InChIKey=KLMGMSFWQGMDTB-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 198912   

TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM198912(US9221802, Ref. Ex. 79 | US9315498, 79)
Affinity DataEC50:  22nMT: 2°CAssay Description:A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
US Patent

TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM198912(US9221802, Ref. Ex. 79 | US9315498, 79)
Affinity DataEC50:  22nMT: 2°CAssay Description:About 24 hrs before an experiment, 5x104 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details
US Patent