BDBM199356 US9221831, 21
SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1)[C@H]1Cc4ccc(C(N)=O)c5O[C@@H]2[C@]3(CCN1C)c45
InChI Key InChIKey=YWZUTHYBZDSTKA-IPRXQQHWSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 199356
Affinity DataKi: 0.150nMpH: 7.4Assay Description:Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recomb...More data for this Ligand-Target Pair
Affinity DataKi: 17.3nM ΔG°: -11.5kcal/molepH: 7.4 T: 50°CAssay Description:Radioligand dose-displacement binding assays for t-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane...More data for this Ligand-Target Pair
Affinity DataKi: 185nM ΔG°: -9.18kcal/molepH: 7.4 T: 25°CAssay Description:Delta-opioid Receptor Binding Assay Procedures were conducted as
follows. Radioligand dose-displacement assays used 0.3 nM
[3H]-Naltrindole (Perkin...More data for this Ligand-Target Pair
Affinity DataKi: 8.62E+3nM ΔG°: -7.48kcal/molepH: 7.4 T: 50°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (Perkin Elmer, Shelton, Conn.; 87.7 Ci/mmole) with 12 ug mem...More data for this Ligand-Target Pair
Affinity DataEC50: 86nMpH: 7.4 T: 25°CAssay Description:Functional [35S]GTPgammaS binding assays were conducted as follows.
Delta opioid receptor membrane solution was prepared by sequentially
adding fin...More data for this Ligand-Target Pair
Affinity DataEC50: 102nMpH: 7.4 T: 25°CAssay Description:[35S]GTPgammaS functional assays were conducted using freshly thawed u-receptor membranes (Perkin Elmer, Shelton, Conn.). Assay reactions
were prepa...More data for this Ligand-Target Pair
Affinity DataEC50: 13.3nMpH: 7.4 T: 25°CAssay Description:Functional [35S]GTPgammaS binding assays were conducted as follows. κ
opioid receptor membrane solution was prepared by sequentially adding
final ...More data for this Ligand-Target Pair